Allopregnanolone

Essential Reads: Neurosteroids, Allopregnanolone and Vulnerability to Depression in Women

Essential Reads: Neurosteroids, Allopregnanolone and Vulnerability to Depression in Women Women are twice as likely as men to suffer from a depressive disorder. In addition, they are vulnerable to mood disorders associated with reproductive functioning, specifically premenstrual dysphoric disorder, perinatal depression, and perimenopausal depression. There is strong evidence to indicate that biological factors (genetic vulnerability,… Read More »

Oral Allopregnanolone Analogue for Postpartum Depression Treatment

In 2015, we first reported on SAGE-547 (SAGE Therapeutics), a new medication for the treatment of postpartum depression (PPD). SAGE-547, now called brexanolone, is a neurosteroid, an analogue of allopregnanolone and an allosteric modulator of GABAA receptors. Since that time, Sage Therapeutics has conducted three randomized controlled trials, enrolling a total of 247 women diagnosed… Read More »